Gallery

Normal and abnormal striatal dynamics in health and disease

Miniature microscope movies of calcium activity in striatal D1 (dSPNs) and D2 (iSPNs) neurons before lesion of dopamine neurons (Pre-lesion), 14 days after lesion (Post-14d) and after treatment with a dyskinesiogenic dose of the dopamine precursor L-DOPA.

For more information see https://www.nature.com/articles/s41586-018-0090-6

PD_LID_Mosaic

Modeling synaptic deficits in the striatum

A confocal z-stack of a dSPN used for dendritic spine quantification.

spn-z-stack

A 3D rendering of the same confocal z-stack.

SPN-3D